Abstract: Published in Explore! For the Professional
HOW PLANT-BASED DETOXIFIERS BENEFIT CHEMICAL DETOXIFIERS
By Stephanie Ray, BCN, ND
The Current State of Detoxification in Human Beings
A state of “man-made versus nature” exists in the world today. Humans manufacture and ingest many substances that cannot be naturally broken down by the human body. These substances exist in our air, water, food, even our teeth1 and include environmental pollutants such as heavy metals, chemicals, pesticides, and plastics. Research shows these pollutants contribute to many health issues in adults and children.3,4,5,6,7
Environmental risk factors play a role in more than 80% of the diseases regularly reported by the World Health Organization.8 In children alone, the costs of environment related disease is estimated at $76.6 billion.9 In adults it is the underlying causal factor in debilitating and costly degenerative diseases. World conditions for men, women, and children make it a priority to address daily and certainly biannual detoxification protocols.
Comparing Detoxification Products: Man-Made vs Nature
This article is an excerpt from a paper published in Explore! For the Professional and serves to examine four heavy metal detoxifiers; DMSA and DMPS, inorganic or man-made detoxifiers and NDF® Detox and NDF Plus® Detox, organic or all natural detoxifying agents. We will discuss their properties, benefits, limitations and how combining natural methods with western medicine provides a safety net while significantly increasing positive results.
Man-made Detoxification: DMSA & DMPS
In the case of man-made or inorganic detoxifiers, these interventions tend to over stimulate and place a burden on different systems in the body. They can also drain nutrients. However, there are times when synthetic supplements are beneficial and necessary. Herbal and food based formulas coming from Mother Nature are organic, provide a synergistic supportive effect when used with inorganic supple-ments while having a balancing impact on the body.
Research shows DMSA and DMPS remove heavy metals from the body including the organs, brain, and connective tissue 12,13 by pulling metals from their binding sites.
Effects on the Body’s Terrain
We must take into consideration the terrain damage that results when these substances are used on their own. Due to the sulfur content, inflammation and dysbiosis in the gut is a common side effect. Studies indicate DMSA and DMPS impair immune function, increase hepatic enzymes and creatinine levels as well as deplete essential nutrients including selenium, zinc, magnesium, manganese, molyb- denum.14,15,16 And since supplementation is needed over an extensive period of time to detoxify toxic heavy metals, using sulfur based chelators alone is inefficient and contraindicated to restoring healthy balance in the body.
Lab Monitoring
Monitoring liver function (SGOT, SGPT, GGT, ALT, AST), kidney function (BUN, creatinine) and Complete Blood Count (CBC) is recommended.
Both are volatile and strong-smelling resulting in a sulfur odor often compared to onions, garlic, and skunk musk. DMPS and DMSA are not recommended when silver amalgam fillings are in the teeth.17,18
Intake Requirements
DMPS requires a prescription and is available in the following forms; pill, transdermal, suppository or intravenous. DMSA is available by prescription or online and is available in pill, suppository or transdermal form. The half life of DMPS and DMSA is approximately 6-8 hours and 4 hours, respectively.19,20
Natural Detoxifiers: NDF and NDF Plus
In the case of natural detoxification: NDF® Detox (Natural Detox Factors) and NDF Plus® Detox (Natural Detox Factors Plus) are all natural detoxifying dietary supplements. The benefits of these two are an increase in the excretion of and binding to toxic heavy metals, chemicals, and pesticides. The chlorella 21,22,23 cell wall in NDF® Detox and NDF Plus® Detox is a mucopolysaccharide ion exchange resin (M.I.E.R) that forms both ionic and double bonds with toxic heavy metals, chemicals, and pesticides and escorts them out of the body.
Beneficial Side Effects
NDF® Detox and NDF Plus® Detox also contain cilantro, 24,25,26 beneficial lysates of 11 beneficial probiotics, 19 amino acids—including the 8 essential amino acids, multiple vitamins and minerals, chlorella growth factor, and live enzymes. Neither NDF® Detox nor NDF Plus® Detox remove beneficial minerals or create imbalances; they are adaptogens, 27 that restore the natural homeostasis in the body and bring essential elements into more “normal” ranges.
Lab Monitoring
In post ingestion heavy metal urine excretion testing, NDF® Detox and NDF Plus® Detox balanced elemental minerals when patients were either high or low during pre ingestion testing. In these same tests an increase in excretion of multiple toxic heavy metals and chemicals were noted. Patients simultaneously, supporting liver, adrenals, and GI, did not experience a detox reaction (footnote Detox Quartet here).
Options for Sensitive Constitutions
NDF® Detox is recommended for those with normal to strong constitutions. NDF Plus® Detox is recommended for those with high stress, compromised immune function, or assimilation issues. Both products are safe to ingest when silver amalgam fillings are in the teeth.
Ease of Intake
NDF® Detox and NDF Plus® Detox are available without a prescription. As liquid dietary supplements, they can be diluted in water or juice, given sublingually, rectally, or using a transdermal application. The half life of NDF® Detox and NDF Plus® Detox is 2 hours.
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Using a proprietary manufacturing process, the active ingredients in NDF® Detox and NDF Plus® Detox are suspended in liquid, assuring rapid absorption and 100% bioavailability. They are natural detoxifiers and are considered adaptogenic biological response modifiers, supporting the immune system.
Di-thiol chelators are drugs and are a man-made engineered approach which makes excretion of heavy metals easier to measure but also stresses the body or creates an imbalanced terrain. When these chelators are given in combination with NDF® Detox or NDF Plus® Detox, an increase in the elimination will occur.
Explore-How-Plant-Based-Detoxifiers-Benefit-Chemical-Detoxifiers.pdf
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REFERENCES
1Clarkson TW, Magos L, Myers G. The toxicology of mercury – current expo-sures and clinical manifestations. N Engl J Med. 2003;349(18):1731-1737.
2Pollutant—a substance that pollutes, especially a chemical or similar substance that is produced as a waste product of an industrial process. (Life Sciences & Allied Applications / Environmental Science) Collins English Dictionary – Complete and Unabridged © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003.
3Matsuda K, Suzuki K, Ishihara S, Morinaga M, Okamoto M, Shiino Y, Horiuchi I, Tohyama K, Ichihara K. Assessment of the severity of organophosphate (feni-trothion) poisoning based on its serum concentration and clinical parameters. Clin Toxicol (Phila). 2011 Nov;49(9):820-7.
Houston MC. Role of mercury toxicity in hypertension, cardiovascular dis-ease, and stroke. J Clin Hypertens (Greenwich). 2011 Aug;13(8):621-7. doi: 10.1111/j.1751-7176.2011.00489.x. Epub 2011 Jul 11.
Geier DA, Geier MR.A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. J Toxicol Environ Health A. 2007 Oct;70(20):1723-30.
Obrenovich ME, Shamberger RJ, Lonsdale D. Altered heavy metals and transke-tolase found in autistic spectrum disorder. Biol Trace Elem Res. 2011 Dec;144(1-3):475-86. Epub 2011 Jul 14.
Winneke G. Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenyls. J Neurol Sci. 2011 Sep 15;308(1-2):9-15. Epub 2011 Jun 15.
Leonardo Trasande, Yinghua Liu. Reducing The Staggering Costs Of Environ-mental Disease In Children, Estimated At $76.6 Billion In 2008. Health Affairs, 2011; DOI: 10.1377/hlthaff.2010.1239
Xu Y, Wang Y, Wang L, Zhao M, Zhang X, Hu X, Hou B, Peng L, Zheng M, Wu J, Peng S. Lead detoxification activities of a class of novel DMSA—amino acid conjugates. Chem Res Toxicol. 2011 Jun 20;24(6):979-84. Epub 2011 May 26.
Bridges CC, Joshee L, Zalups RK. Effect of DMPS and DMSA on the placental and fetal disposition of methylmercury. Placenta. 2009 Sep;30(9):800-5. Epub 2009 Jul 16.
Clarkson TW, Magos L, Myers G. The toxicology of mercury – current expo-sures and clinical manifestations. N Engl J Med. 2003;349(18):1731-1737. Pollutant—a substance that pollutes, especially a chemical or similar substance that is produced as a waste product of an industrial process. (Life Sciences & Allied Applications / Environmental Science) Collins English Dictionary – Com-plete and Unabridged © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003.
Matsuda K, Suzuki K, Ishihara S, Morinaga M, Okamoto M, Shiino Y, Horiuchi I, Tohyama K, Ichihara K. Assessment of the severity of organophosphate (feni-trothion) poisoning based on its serum concentration and clinical parameters. Clin Toxicol (Phila). 2011 Nov;49(9):820-7.
Houston MC. Role of mercury toxicity in hypertension, cardiovascular dis-ease, and stroke. J Clin Hypertens (Greenwich). 2011 Aug;13(8):621-7. doi: 10.1111/j.1751-7176.2011.00489.x. Epub 2011 Jul 11.
Geier DA, Geier MR.A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. J Toxicol Environ Health A. 2007 Oct;70(20):1723-30.
Obrenovich ME, Shamberger RJ, Lonsdale D. Altered heavy metals and transke-tolase found in autistic spectrum disorder. Biol Trace Elem Res. 2011 Dec;144(1-3):475-86. Epub 2011 Jul 14.
Winneke G. Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenyls. J Neurol Sci. 2011 Sep 15;308(1-2):9-15. Epub 2011 Jun 15.
Leonardo Trasande, Yinghua Liu. Reducing The Staggering Costs Of Environ-mental Disease In Children, Estimated At $76.6 Billion In 2008. Health Affairs, 2011; DOI: 10.1377/hlthaff.2010.1239
Xu Y, Wang Y, Wang L, Zhao M, Zhang X, Hu X, Hou B, Peng L, Zheng M, Wu J, Peng S. Lead detoxification activities of a class of novel DMSA—amino acid conjugates. Chem Res Toxicol. 2011 Jun 20;24(6):979-84. Epub 2011 May 26.
Bridges CC, Joshee L, Zalups RK. Effect of DMPS and DMSA on the placental and fetal disposition of methylmercury. Placenta. 2009 Sep;30(9):800-5. Epub 2009 Jul 16.
Sharma V, Kansal L, Sharma A. Prophylactic efficacy of Coriandrum sati-vum (Coriander) on testis of lead-exposed mice. Biol Trace Elem Res. 2010 Sep;136(3):337-54. Epub 2009 Nov 10.
V. F. Furletti, I. P. Teixeira, G. Obando-Pereda, R. C. Mardegan, A. Sartoratto, G. M. Figueira, R. M. T. Duarte, V. L. G. Rehder, M. C. T. Duarte, and J. F. Höfling Action of Coriandrum sativum L. Essential Oil upon Oral Candida albicans Biofilm Formation. Evid Based Complement Alternat Med. 2011; 2011: 985832.
B. Ley. Chlorella The Ultimate Green Food. Pg. 48, 2003; ISBN 1-890766-28-3
